I think different is good as long as it's useful and pleasant to navigate. Now if different means crazy colors and a confusing layout then I would say stay away but it really depends on what you mean when you say "different". And of course you can always ask for a review in the Site Review forum as you're testing different layouts.
I have never used a CMS but just make sure that the pages the system generates is search engine friendly. I think most systems are now making the pages so they are, but you definitely want to do your research beforehand.
Joomla is also another popular open source CMS you may want to check out. Some members here have given good reviews on it.
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