Keywords are becoming less and less important. At best, some believe they are used by AdSense (and other ad serving programs) to help determine ad relevancy but even that hasn't been proven. You should definitely use them but I wouldn't put too much time into them.
I generally use 2-3 keyword phrases separated by commas and I try to make sure they match the content of my page as much as I can. No sense in loading up your meta tags with hundreds of keywords or stressing over which are best. Just pick a few and make sure they're relevant.
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